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Displaying 11 - 20 of 21 results.

On the origin of Ebola: Biomedical discourse versus popular interpretations in Macenta in Guinea

This resource describes the use of participative observation, informal conversations and in-depth interviews to identify rumours surrounding Ebola, their sources, and to understand the local population’s perception and knowledge about the history and origin of the Ebola outbreak in Guinea. 

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Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa

This resource describes the main challenges of the implementation of a trial in the Ebola treatment center of Guéckédou. Following the principles of the Good Clinical Research Practices, it reports the aspects of the community’s communication and engagement, ethical conduct, trial protocol compliance, informed consent of participants, ongoing benefit/risk assessment, record keeping, confidentiality of patients and study data, and roles and responsibilities of the actors involved.

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'He is now like a brother, I can even give him some blood': Relational ethics and material exchanges in a malaria vaccine 'trial community' in The Gambia

This paper explores social relations within the ‘trial community’ (staff and volunteers) of a Malaria Vaccine Trial (MVT), implemented by the Medical Research Council (MRC) in The Gambia between 2001 and 2004. It situates ethical concerns with medical research within the everyday life of scientific fieldwork. Based upon discussions with volunteers and staff, it looks at processes of mediation between scientific project and study population, between formal ethics, local ethical debates, and everyday practice.

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Popular concerns about medical research projects in sub-Saharan Africa – a critical voice in debates about medical research ethics

This resource aims to move beyond the dismissal of stories about blood-stealing and trade in body parts as ‘mere’ rumour, based on erroneous belief or traditional superstition, and to instead appreciate them as modern commentaries on social relations that involve, and extend far beyond, scientific medical research.

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EBOVAC-Salone: Lessons learned from implementing an Ebola vaccine trial in an Ebola-affected country

This article describes the experiences of the EBOVAC-Salone research team in setting up and implementing the trial, and provides recommendations for research teams aiming to conduct clinical trials in future outbreak situations.

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When experiments travel: Clinical trials and the global search for human subjects

This book aims to challenge conventional understandings of the ethics and politics of transnational science and change the way we think about global medicine and the new infrastructures of our lives. It explores the clinical trials industry through both an economic and cultural lens to examine the ways commercial medical science is currently being integrated into local health systems.

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WHO: Efficacy trials of Lassa therapeutics: endpoints, trial design, site selection

This resource is a final report of a WHO workshop regarding efficacy trials of Lassa therapeutics. 

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WHO: Target product profile for Lassa virus vaccine

This resource is an outline of the WHO target product profile development  for Lassa, as well as a generic description of WHO's Vaccine Pre-qualification process.

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Emerging disease or emerging diagnosis?: Lassa fever and Ebola in Sierra Leone

This article looks beyond Ebola in 2014 to the history of efforts to control VHFs in the Mano River and challenges the idea that there was a vacuum of knowledge. Highlighted instead are politics of knowledge which have run through global health and which have prioritized particular forms of knowledge and ways of dealing with disease. Ethnographic research on the emergence of Lassa and the subsequent emergence of Ebola in West Africa is presented, focusing on the development of technologies and institutions to detect and manage both viruses.

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Epidemics: Science, governance, and social justice

This book focuses on how different policy-makers, scientists, and local populations construct alternative narratives-accounts of the causes and appropriate responses to outbreaks- about epidemics at the global, national and local level. The contrast between emergency-oriented, top-down responses to what are perceived as potentially global outbreaks and longer-term approaches to diseases, such as AIDS, which may now be considered endemic, is highlighted.

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