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Displaying 1 - 10 of 22 results.

Lassa Fever: a rodent-human interaction

This resource examines the sites of interactions between humans and the multimammate mouse, Mastomys natalensis. It presents findings such as new arenaviruses in other African rodents and in snakes, that  argue preferably toward the host-switching concept. The recent emergence in Sierra Leone, the absence of virus positive Mastomys between the two endemic zones and poor virus diversity in the Mano River area also point in the direction of a unique import of Lassa virus from Nigeria to Sierra Leone during the 19th century. This resource also discusses the hypothesis of human displacements through the Atlantic slave trade and its abolition in 1807.

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Diversity and dynamics in a community of small mammals in coastal Guinea, West Africa

This resource investigated three villages in high endemic zones of Lassa fever in Guinea and presents the biodeiversity of the small mammal community identified through standardized trapping in houses, cultivations and forest.

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Forecasting rodent outbreaks in Africa: an ecological basis for Mastomys control in Tanzania

This study collected rainfall data preceding historical outbreaks of Mastomys rats in East Africa in order to test the hypothesis that such outbreaks occur after long dry periods. It found that rodent outbreaks were generally not preceded by long dry period and the population dynamics of Mastomys natalensis rats in Tanzania are significantly affected by the distribution of rainfall during the rainy season.

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Acute sensorineural deafness in Lassa fever

This resource describes a prospective audiometric evaluation of 69 hospitalized febrile patients in Sierra Leone, West Africa, that revealed a sensorineural hearing deficit (SNHD) in 14 (29%) of 49 confirmed cases of Lassa fever and in 0 of 20 febrile controls. This study found that lassa fever is associated with an incidence of SNHD, which considerably exceeds that previously reported with any other postnatally acquired infection.

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Therapy management: Concept, reality, process

This resource described the two concepts of "therapy management" (diagnosis, selection, and evaluation of treatment, as well as support of the sufferer) and "therapy management group" (the set of individuals who take charge of therapy management with or on behalf of the sufferer) as developed in medical anthropology research in Central Africa. It explores their historical development, current use by researchers, and potential future uses in contextually sensitive analyses. 

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Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

This resource summarises clinical findings of hearing loss in Lassa fever (LF) patients highlighting the association between Lassa virus infection and sudden-onset sensorineural hearing loss (SNHL), as well as the potential mechanism(s) for LF-induced SNHL. The study highlights that further research is necessary to identify the mechanism and the epidemiology of LF-induced SNHL.

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Sensorineural hearing loss in Lassa fever: Two case reports

This resource reports on two female patients aged 19 and 43 years old with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific reverse transcriptase polymerase chain reaction. Both patients developed severe sensorineural hearing loss at acute phases of the infections.

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Organizing the donation of convalescent plasma for a therapeutic clinical trial on Ebola Virus Disease: The experience in Guinea

This resource reports on the successful organization of donor mobilization and plasma collection as part of the Ebola-Tx clinical trial from November 2014 to July 2015 in Conakry, Guinea, the challenges they faced, and efforts made to address these.

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Healthcare providers on the frontlines: A qualitative investigation of the social and emotional impact of delivering health services during Sierra Leone’s Ebola epidemic

This paper describes the stigma experienced by health care workers during the Ebola epidemic in Sierra Leone, and recommends psychological support mechanisms for medical staff working in epidemic contexts.

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Dealing with the unseen: Ffear and stigma in Lassa fever

This poster reports on research carried out with patients and caregivers at Irrua hospital.  It shows how many patients feared telling their family members that they were infected with Lassa Fever, and some were rejected by their family who refused to care for them.

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